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Aetiology
Cohort study
Raised blood glucose as a predictor of dementia risk in adults with and without diabetes
  1. Leigh Martin Riby1,
  2. Deborah Michelle Riby2
  1. 1Department of Psychology, Northumbria University, Newcastle, UK
  2. 2Department of Psychology, Durham University, Durham, UK
  1. Correspondence to : Dr Leigh Martin Riby, Department of Psychology, Northumbria University, City Campus, Newcastle NE1 8ST, UK; leigh.riby{at}northumbria.ac.uk

https://doi.org/10.1136/eb-2013-101557

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    Commentary on: Crane PK, Walker R, Hubbard RA, et al. Glucose levels and risk of dementia. N Engl J Med 2013;369:540–8.OpenUrlCrossRefPubMedWeb of Science

    Context

    Research has suggested that diabetic status doubles the risk of dementia.1 There is also a suggestion that efficient glucose regulation in healthy older adults contributes to the stability of cognitive skills, particularly in domains subserved by the hippocampus (eg, episodic memory which is known to decline in dementia).2 Consequently, the present work is a timely contribution in understanding the relationship between the blood glucose and risk for dementia.

    Methods

    The incidence of dementia was assessed longitudinally at 2-year intervals for 2067 dementia-free older adults from the Adult Changes in Thought Study. This community cohort consists of 839 men, 1228 women, 232 with diabetes at baseline, and a baseline mean age …

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    Footnotes

    • Competing interests None.