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Harm
Cohort study
Inhaled fluticasone and budesonide increased the risk of serious pneumonia in COPD
  1. Patrick White
  1. Department of Primary Care & Public Health Sciences, Kings College London, London, UK
  1. Correspondence to : Dr Patrick White, Primary Care & Public Health Sciences, Kings College London, 9th Floor Capital House, 42 Weston Street, London SE1 3QD, UK; patrick.white{at}kcl.ac.uk
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http://dx.doi.org/10.1136/eb-2013-101695

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    Commentary on: Suissa S, Patenaude V, Lapi F, et al. Inhaled corticosteroids in COPD and the risk of serious pneumonia. Thorax 2013;68:1029–36.OpenUrlAbstract/FREE Full Text

    Context

    High-dose inhaled corticosteroids (ICS) reduce the rate of exacerbations in severe and very severe chronic obstructive pulmonary disease (COPD) when prescribed with inhaled long-acting β-agonists (LABA).1 ,2 Although LABA+ICS use is now universally recommended for severe and very severe COPD, the magnitude of their effect is disputed and they are associated with a higher risk of pneumonia.3 Risk of pneumonia has been associated particularly with fluticasone propionate, and less clearly with budesonide.4 ,5 Equivalence of potency between different …

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    • Competing interests None.

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