Article Text

Download PDFPDF
Systematic review and meta-analysis
Advanced wound care therapies in non-healing lower extremity ulcers: high expectations, low evidence
  1. Katherine Leslie Baquerizo Nole,
  2. Robert S Kirsner
  1. Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, Florida, USA
  1. Correspondence to : Dr Robert S Kirsner, Department of Dermatology and Cutaneous Surgery, University of Miami, 1321 NW 14th St, West Building Room 504, Miami, FL 33136, USA; rkirsner{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Commentary on: OpenUrlCrossRefPubMedWeb of Science


Chronic lower extremity (LE) ulcers represent a major challenge to healthcare systems worldwide. In the USA, they affect an estimated 2.5–4.5 million people. The most common chronic LE wounds are venous leg ulcers (VLU), diabetic foot ulcers (DFU) and arterial ulcers (AU).1 Since standard care (SC) heals only between 30% and 75% of VLUs and between 24% and 31% of DFUs,2 ,3 additional therapies for non-healing ulcers are needed.


This was a systematic review of randomized controlled trials (RCTs) of approved advanced care therapies in healing of DFUs, VLUs and AUs. …

View Full Text


  • Competing interests RK is a consultant for Shire Pharmaceuticals and Organogenesis.