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  • Meta-analysis finds benefit for dual antiplatelet therapy but limitations preclude changing standard mono antiplatelet therapy approach for acute non-cardioembolic ischaemic stroke or transient ischaemic attack

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Therapeutics
Systematic review and meta-analysis
Meta-analysis finds benefit for dual antiplatelet therapy but limitations preclude changing standard mono antiplatelet therapy approach for acute non-cardioembolic ischaemic stroke or transient ischaemic attack
  1. Wilbert S Aronow
  1. Division of Cardiology, New York Medical College/Westchester Medical Center, Valhalla, New York, USA
  1. Correspondence to : Dr Wilbert S Aronow, Division of Cardiology, New York Medical College, Macy Pavilion, Room 138, Valhalla, NY 10595, USA; wsaronow{at}aol.com

http://dx.doi.org/10.1136/eb-2013-101649

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    Commentary on: Wong KSL, Wang Y, Leng X, et al. Early dual versus mono antiplatelet therapy for acute non-cardioembolic ischemic stroke or transient ischemic attack. An updated systematic review and meta-analysis. Circulation 2013;128:1656–66.OpenUrlAbstract/FREE Full Text

    Context

    Current guidelines recommend aspirin, aspirin plus clopidogrel or aspirin plus extended-release dipyridamole for treatment of acute ischaemic stroke (IS) or transient ischaemic attack (TIA) to prevent recurrent stroke, myocardial infarction and cardiovascular death.1 The Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial randomised 5170 Chinese patients within 24 h after the onset of IS or TIA to clopidogrel plus aspirin versus aspirin plus placebo for 90 days. Clopidogrel plus …

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