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  • The addition of nebulised magnesium to the standard asthma therapy for children with severe symptoms results in small improvements in asthma severity scores

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Therapeutics
Randomised controlled trial
The addition of nebulised magnesium to the standard asthma therapy for children with severe symptoms results in small improvements in asthma severity scores
  1. Joseph J Zorc
  1. Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
  1. Correspondence to : Dr Joseph J Zorc, CTRB 9004, The Children's Hospital of Philadelphia, 34th and Civic Center Blvd, University of Pennsylvania, Philadelphia, PA 19104, USA; zorc{at}email.chop.edu

https://doi.org/10.1136/eb-2013-101688

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    Commentary on: Powell C, Kolamunnage-Dona R, Lowe J, et al. MAGNEsium Trial In Children (MAGNETIC): a randomised, placebo-controlled trial and economic evaluation of nebulised magnesium sulphate in acute severe asthma in children. Health Technol Assess 2013;17:1–216.OpenUrlWeb of Science

    Context

    The prior research has found that magnesium sulfate given intravenously acts as a bronchodilator and improves airway obstruction in status asthmaticus.1 The intravenous route requires substantial resources for administration and close monitoring due to concerns for adverse effects, such as hypotension. Several studies have suggested that nebulised magnesium may also have benefits.2 If the efficacy was demonstrated for nebulised magnesium, it could be added to bronchodilators in the standard asthma treatment protocols, providing an important advance in the treatment …

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    Footnotes

    • Competing interests None.