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Randomised controlled trial
Topical antibiotic therapy is superior to systemic antibiotics for acute tympanostomy tube otorrhoea, but may not be necessary for all children
  1. Richard M Rosenfeld
  1. Department of Otolaryngology, SUNY Downstate Medical Center, Brooklyn, New York, USA
  1. Correspondence to: Dr Richard M Rosenfeld, Department of Otolaryngology, SUNY Downstate Medical Center, 450 Clarkson Avenue, MSC 126, Brooklyn, NY 11203, USA; richrosenfeld{at}

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Commentary on: OpenUrlCrossRefPubMedWeb of Science


Tympanostomy tube insertion is the most common ambulatory surgery performed on children.1 Discharge from the ear canal (otorrhoea) is the most common sequela of tubes, with a mean incidence of 26% in observational studies and up to 83% with prospective surveillance.2 ,3 Acute tympanostomy tube otorrhoea (TTO) is usually a manifestation of acute otitis media and may occur during a viral upper respiratory infection or when water penetrates the tube and enters the middle ear space.


This open-label, pragmatic trial included 230 Dutch children aged 1–10 years with acute TTO (lasting up to 7 days) who were assigned randomly to three groups: (1) topical antibiotic eardrops …

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  • Competing interests None.