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Randomised controlled trial
An intensive outpatient lifestyle modification programme improves measures of glycaemia in obese youth
  1. Amy Fleischman
  1. Boston Children's Hospital, Boston, Massachusetts, USA
  1. Correspondence to: Dr Amy Fleischman, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA; amy.fleischman{at}

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The worldwide epidemic in paediatric obesity has caused an increase in metabolic abnormalities, including type -2 diabetes (T2DM). Precursors of T2DM include insulin resistance and β-cell dysfunction, resulting in hyperglycaemia and insufficient insulin response. The oral glucose tolerance test (OGTT) has been the gold standard for diagnosing diabetes and impaired glucose tolerance (IGT). While lifestyle interventions have delayed or prevented the progression from IGT to T2DM in adults, the data in children are limited and demonstrate varying efficacy.1 Furthermore, intensive lifestyle interventions in children are practically difficult.


The study describes a 6-month, randomised controlled trial of the impact of the Bright Bodies Healthy …

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  • Competing interests None.