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Cohort study
Combined HPV and cytology better than cytology for protection against cervical cancer
  1. Mack Ruffin
  1. Department of Family Medicine, University of Michigan, Ann Arbor, Michigan, USA
  1. Correspondence to: Dr Mack Ruffin, Department of Family Medicine, University of Michigan, 1018 Fuller Street, Ann Arbor, MI 48104-1213, USA; mruffin{at}

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Over the past 20 years, cervical cancer screening guidelines have evolved from advising performance of cervical cytology on every sexually active woman every year, to advising no screening on women under the age of 21 years and use of cervical cytology every 3 years only in women aged 30–65 years with an intact cervix.1 Many clinicians use human papillomavirus (HPV) testing with cervical cytology to triage abnormal cytology. Others have begun to use HPV alongside normal cytology. The data to support this strategy was based solely on protection from cervical …

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  • Competing interests None.