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Cohort study
Digoxin initiation is associated with lower risk of all-cause readmission after hospitalisation for heart failure
  1. Adrian F Hernandez1,
  2. Adam D DeVore2
  1. 1Department of Cardiology, Duke University School of Medicine, Durham, North Carolina, USA;
  2. 2Duke University Medical Center, Durham, North Carolina, USA
  1. Correspondence to: Dr Adrian F Hernandez, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA; adrian.hernandez{at}

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The use of digoxin for the treatment of heart failure dates back to the 18th century, yet controversy remains about its safety and efficacy. The largest clinical trial of digoxin concluded that digoxin had no effect on mortality but did improve the rate of rehospitalisation for patients with chronic heart failure.1 With increasing focus on readmissions, there are limited data to understand the impact of digoxin initiated during hospitalisation for acute heart failure on postdischarge outcomes.


The authors analysed data from chart abstractions and Medicare claims of patients hospitalised with acute heart failure to assess the impact of digoxin on postdischarge …

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  • Competing interests None.