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Birth weight is inversely associated with risk of cardiovascular disease. The exact timing of the fetal growth disturbances that underpin this association are poorly described. This study examines the association of first trimester fetal growth with cardiovascular risk factors, and risk factor clustering, in children.
This was a longitudinal cohort study (the Generation R Study) of pregnant women and their offspring in Rotterdam, the Netherlands. Of 8880 women enrolled, this analysis was restricted to 1184 of the offspring with data for first trimester crown-to-rump length, reliable gestational age data and cardiovascular risk measured at 6 years of age (90% range 5.7–6.8 years); 745 had data for clustering of risk factors. First …
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