You are here

  • Home
  • Archive
  • Volume 19, Issue 5
  • The difference in sensitivity between HPV testing and cytology for detecting current and future CIN2+ increases over time

Article Text

Article menu
Download PDFPDF
Prevention
Randomised controlled trial
The difference in sensitivity between HPV testing and cytology for detecting current and future CIN2+ increases over time
  1. Peter Sasieni
  1. Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  1. Correspondence to : Professor Peter Sasieni, Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK; p.sasieni{at}qmul.ac.uk

http://dx.doi.org/10.1136/eb-2014-101757

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Commentary on: Elfström KM, Smelov V, Johansson AL, et al. Long term duration of protective effect for HPV negative women: follow-up of primary HPV screening randomised controlled trial. BMJ 2014;348:g130.OpenUrlAbstract/FREE Full Text

    Context

    Human papillomavirus (HPV) testing is more sensitive but less specific than cytology for detecting CIN2+.1 Longitudinally, the cumulative rate of CIN2+ 6 years after a negative HPV test is similar to the rate 3 years after negative cytology.2 However, some researchers have suggested that this improved sensitivity is due to overdiagnosis of regressive lesions.3 Meta-analysis of randomised controlled trials shows that screening with HPV testing prevents more cervical cancers than with cytology.4 There is little evidence regarding CIN2+ more than 6 years after HPV testing.

    Methods

    Consenting women aged 32–38 were randomised between HPV and cytology double testing (n=6257) and cytology alone (n=6270). Stored samples from the control arm were tested for …

    View Full Text

    Footnotes

    • Competing interests None.