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Harm
Cohort study
Intussusception risk increased after rotavirus vaccination but outweighed by benefits
  1. Evan J Anderson1,2,
  2. Bethany K Sederdahl1
  1. 1Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
  2. 2Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
  1. Correspondence to : Dr Evan J Anderson, Departments of Pediatrics, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA; evanderson{at}emory.edu

https://doi.org/10.1136/eb-2014-101793

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    Commentary on: Weintraub ES, Baggs J, Duffy J, et al. Risk of intussusception after monovalent rotavirus vaccination. N Engl J Med 2014;370:513–19.OpenUrlCrossRefPubMedWeb of Science And Yih WK, Lieu TA, Kulldorff M, et al. Intussusception risk after rotavirus vaccination in U.S. infants. N Engl J Med 2014;370:503–12.OpenUrlCrossRefPubMedWeb of Science

    Context

    Prior to the introduction of paediatric rotavirus vaccination, rotavirus was the most common cause of infectious gastroenteritis to result in the hospitalisation of children and accounted for about 450 000 deaths in children per year worldwide.1 Use of the first rotavirus vaccine, RotaShield (Wyeth Lederle), was discontinued within 1 year of US licensure after intussusception was identified in about 1 of every 10 000 children within 2 weeks of vaccination.2

    Two new rotavirus vaccines, RotaTeq (RV5, Merck) and Rotarix (RV1, GlaxoSmithKline), when assessed in prelicensure studies of >60 000 infants were not associated with an increased risk of intussusception. Since US licensure of RV5 in 2006 and RV1 in 2008, these vaccines have been carefully monitored for safety. Postlicensure studies in Mexico, Brazil and Australia have identified a relationship between …

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    Footnotes

    • Competing interests None.