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In 2013, new guidelines for the treatment of cholesterol for the prevention of cardiovascular disease (CVD) were issued by the American College of Cardiology and the American Heart Association (ACC-AHA), based on a systematic review of lipid lowering trials and meta-analyses evaluating treatment impact on CVD morbidity and mortality, and quantitated adverse effects of lipid-lowering therapy.1 Many of these trials were reported after publication of the NIH-issued Third Adult Treatment Panel (ATPIII) lipid-lowering guidelines.2 The new guidelines feature modified eligibility criteria for cholesterol-lowering treatment based on estimation of benefits and harms of therapy in specific population subsets, and recommend use of a new risk calculator which …
Competing interests VB is an investigator in clinical trials sponsored by Sanofi-Aventis/Regeneron, Amgen, Pfizer, Janssen, GlaxoSmithKline, Bayer Healthcare, AstraZeneca and Merck. She has consulted for Amarin and Novartis.
Provenance and peer review Commissioned; internally peer reviewed.