Table of contents

Therapeutics

• Post hoc analysis of RCT: Intensive glucose-lowering results in increased cardiovascular mortality in younger but not older individuals with type 2 diabetes (15 July, 2014)

  Francesco Giorgino
• Systematic review and meta-analysis: Oseltamivir and zanamivir have limited effect on symptoms and do not reduce hospitalisation or serious complications of influenza (1 July, 2014)

  Mark H Ebell
• Randomised controlled trial:

  Lactobacillus reuteri is an effective option for the prevention of diarrhoea in preschool children but may not be cost-effective in all settings

  (11 July, 2014)

  Yvan Vandenplas
• Randomised controlled trial: Individualised pelvic floor muscle training is an effective conservative treatment in women with pelvic organ prolapse (18 July, 2014)

  S Abbas Shobeiri, Andrea C Santiago
• Systematic review: Calcium channel blockers are effective as first line for tocolysis in the management of preterm labour (27 August, 2014)

  Richard G Brown, David A MacIntyre
• Randomised controlled trial:

  Study concludes L. reuteri not effective for infant colic, but findings may be limited by participants' heterogeneity

  (27 August, 2014)

  Flavia Indrio
• Randomised controlled trial: Sham treatment shows similar effects on pain and function compared to a multimodal physiotherapeutic intervention programme in patients with painful hip osteoarthritis (27 August, 2014)

  Inga Krauss
• Systematic review with meta-analysis: Induction of labour decreases a woman's chance of caesarean delivery when compared with expectant management (2 September, 2014)

  Rosalie Grivell
• Systematic review with meta-analysis: ACE inhibitors are associated with a reduction in all-cause mortality versus angiotensin II receptor blockers in patients with diabetes mellitus (27 August, 2014)

  Ziv Harel, Samuel A Silver
• Randomised controlled trial: Pro-vaccine messages may be counterproductive among vaccine-hesitant parents (2 September, 2014)

  Helen Bedford
• Cohort study: At 15 years of follow-up, bariatric surgery, especially when performed within the first year, is associated with diabetes remission and reduced incidence of microvascular and macrovascular complications (11 August, 2014)

  Arya M Sharma
• Systematic review with meta-analysis: Psychological therapies help reduce headache and non-headache pain in children and adolescents (2 September, 2014)

  Johan W S Vlaeyen, Rena Gatzounis
• Systematic review and meta-analysis: Rate and rhythm control have comparable effects on mortality and stroke in atrial fibrillation but better data are needed (21 August, 2014)

  Dipak Kotecha, Paul Kirchhof
• Randomised controlled trial: Ledipasvir/Sofosbuvir administration achieves very high rate of viral clearance in patients with HCV genotype 1 infection without cirrhosis, regardless of ribavirin co-administration or length of treatment (15 July, 2014)

  Ivan Gentile, Guglielmo Borgia
• Randomised controlled trial: Questions linger over POISE-2 and perioperative aspirin management (1 July, 2014)

  Neal Stuart Gerstein, Gerald A Charlton
• Systematic review with meta-analysis: Surveillance for hepatocellular carcinoma with ultrasound and AFP is associated with improvements in tumour detection, receipt of curative therapy and overall survival in patients with cirrhosis (31 July, 2014)

  Danielle A Bischof, Timothy M Pawlik
• Cohort study: Azithromycin associated with a reduction in 90-day mortality among older pneumonia patients, although a true clinical benefit is uncertain (13 August, 2014)

  Wayne A Ray
• Randomised controlled trial: Until questions on intraprocedural efficacy control, renal nerve distribution and predictors of BP response are answered, the interpretation of clinical trials on renal denervation will remain uncertain (27 August, 2014)

  Luca Donazzan, Sebastian Ewen, Michael Böhm
• Randomised controlled trial: RIVUR trial offers confirmatory evidence for a small but real benefit of antibiotics for UTI prevention in children (4 September, 2014)

  Gabrielle Williams, Jonathan Craig
• Systematic review and meta-analysis: If pharmacotherapies for alcohol use disorders are effective, why are they underutilised? (21 August, 2014)

  Elizabeth M Oliva, Alex H S Harris