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Infantile hypertrophic pyloric stenosis (IHPS) is a potentially life-threatening condition for which surgical treatment yields excellent patient outcomes.1 However, the aetiology of IHPS remains elusive. Prior studies have implicated early neonatal exposure to erythromycin as a strong risk factor for IHPS, but it is less clear whether maternal use in late pregnancy or while breastfeeding also poses a risk.2 Perinatal exposure to macrolide antibiotics is not uncommon. About 1% of pregnant women report use in the third trimester, and while no macrolides are licensed by the US Food and Drug Administration for use in infants less …
Footnotes
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Competing interests None.
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Disclaimer The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
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Provenance and peer review Commissioned; internally peer reviewed.