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  • Updated review identifies no adverse impact on mother or offspring during the perinatal period of aspirin use for prevention of preeclampsia

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Therapeutics/Prevention
Systematic review
Updated review identifies no adverse impact on mother or offspring during the perinatal period of aspirin use for prevention of preeclampsia
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  1. Paul Leeson
  1. Division of Cardiovascular Medicine, University of Oxford, Oxford, UK
  1. Correspondence to : Professor Paul Leeson, Oxford Cardiovascular Clinical Research Facility, John Radcliffe Hospital, Oxford OX3 9DU, UK; paul.leeson{at}cardiov.ox.ac.uk

https://doi.org/10.1136/ebmed-2014-110056

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    Commentary on: Henderson JT, Whitlock EP, O'Connor E, et al. Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the US Preventive Services Task Force. Ann Intern Med 2014;160:695–703.OpenUrlCrossRefPubMedWeb of Science

    Context

    Aspirin is recommended in current international guidelines for women at heightened risk for preeclampsia. Preeclampsia occurs in 2–8% of pregnancies and is a leading cause for both maternal and fetal morbidity and mortality. Effective prevention approaches therefore have the potential for significant health benefits. In 1996 the US Preventive Services Task Force produced a report on the identification, prevention and treatment of preeclampsia, stating:There is insufficient evidence to recommend for or against routine aspirin prophylaxis in pregnancy for the prevention of either preeclampsia […] or intrauterine growth retardation […]. Clinicians may wish to inform patients at high risk of preeclampsia that aspirin prophylaxis has been shown to …

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