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The possible association of maternal caffeine intake to a variety of pregnancy outcomes (eg, low birth weight (LBW), fetal growth restriction, preterm delivery) is important because of widespread exposure to caffeine. If caffeine were causally related to these outcomes, it would be amenable to risk reduction through caffeine reduction or abstention.
This was a systematic review and meta-analysis of prospective observational studies of maternal caffeine exposure and LBW. The Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines were followed. Acceptable standards for literature searching, study selection and data extraction were adhered …