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We read with interest the comments by Dr Vozoris1 on our paper “Safety of benzodiazepines and opioids in very severe respiratory disease.”2 We are concerned that his comments might give the impression that opioids should not be used in patients with severe chronic obstructive pulmonary disease (COPD). This could contribute to symptomatic undertreatment and unnecessary suffering.
The main finding of the study should be emphasised: treatment with regular, low-dose opioids (≤30 mg oral morphine equivalents per day) was not associated with increased rates of …