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Systematic review with meta analysis
Meta-analysis compares anticoagulant strategies in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention
  1. Giuseppe Patti
  1. Campus Bio-Medico University—Cardiovascular Sciences, Rome, Italy
  1. Correspondence to : Dr Giuseppe Patti, Campus Bio-Medico University—Cardiovascular Sciences, Via Alvaro del Portillo, 200, Rome 00128, Italy; g.patti{at}

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Optimal anticoagulant therapy in patients receiving primary intervention for acute myocardial infarction (MI) is widely debated. Prior studies have been heterogeneous in doses and concomitant treatments such that it has been unclear whether effects have been those of newer medication or a result of changes in these co-interventions. A meta-analytic approach can allow comparisons between multiple anticoagulant strategies and can help clarify heterogeneity and address power in pooled analyses.


The authors performed a study-level meta-analysis on 22 randomised controlled trials including patients with ST-elevation MI who were undergoing stent …

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  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.