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Prognosis
Randomised controlled trial
Breast feeding and timing of introduction of gluten in infant foods are not predictors of coeliac disease at age 5
  1. Ketil Størda
  1. Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
  1. Correspondence to : Dr Ketil Stordal, Division of Epidemiology, Norwegian Institute of Public Health, Box 4404 Nydalen, 0403 Oslo, Norway; ketil.stordal{at}gmail.com

https://doi.org/10.1136/ebmed-2014-110123

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    Commentary on: Lionetti E, Castellaneta S, Francavilla R, et al.; SIGENP (Italian Society of Pediatric Gastroenterology, Hepatology, and Nutrition) Working Group on Weaning and CD Risk. Introduction of gluten, HLA status, and the risk of celiac disease in children. N Engl J Med 2014;371:1295–303.OpenUrlCrossRefPubMedWeb of Science

    Context

    The presence of gluten in the diet is required for the development of coeliac disease. In genetically predisposed individuals, coeliac disease may start from the introduction of gluten in infancy until any age.1 Early exposure to gluten in the diet has been scrutinised, driven by epidemic increases observed in Sweden in the 1980s after changes mainly in the dose of gluten at introduction.2 Observational studies in a high-risk cohort and in a population-based study have indicated that the timing of gluten …

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    Footnotes

    • Competing interests None.

    • Provenance and peer review Commissioned; internally peer reviewed.