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Systematic review with meta analysis
Uncertainty remains about early pregnancy outcomes after treatment for cervical intraepithelial neoplasia
  1. Kristyn Mary Manley1,
  2. Tim Draycott2
  1. 1Department of Gynaecological Oncology, University Hospitals Bristol, Bristol, UK
  2. 2Department of Women's Health, North Bristol Trust, Bristol, UK
  1. Correspondence to : Kristyn Manley, Department of Womens Health, University Hospitals Bristol, BS2 8EG, UK; Kristyn.Manley{at}

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The introduction of a cervical screening programme has reduced the overall mortality rate from cervical cancer by 60% in the UK, mainly through pre-emptive treatment of the precursor lesion, cervical intraepithelial neoplasia (CIN).1 ,2 Each year, 22 430 women will have excisional or ablative treatments for CIN and many of these women will be of reproductive age.2 Previous studies have reported an increased risk of preterm labour (<37 weeks) and lower birth weight (<2500 g) following excisional treatments for CIN.3 However, there is limited data relating to the effects on conception and first and second trimester outcomes.


MEDLINE and EMBASE searches were conducted. Stated outcomes were overall rates of miscarriage, first trimester (<12 weeks) …

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  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.