Statistics from Altmetric.com
Commentary on: OpenUrl
Benzodiazepines (BZ) are widely prescribed for older patients. They have Food and Drug Administration (FDA) indications for a number of conditions including generalised anxiety disorder, panic disorder and insomnia. However, there are many worries about safety in the elderly including withdrawal, tolerance, ataxia, drug–drug interactions and adverse effects on cognition. For these reasons most guidelines recommend against long-term use of BZ. The study presents evidence for another type of toxicity, namely increasing the risk of incident Alzheimer's disease (AD) in the elderly.
A case–control epidemiological observational study using a large pharmacy database for the province of Quebec was performed. Patients with a diagnosis of AD (1796) were randomly sampled with 7184 controls matched on sex, age group and …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.