Statistics from Altmetric.com
Despite decreasing incidence in many countries, severe infections caused by methicillin-resistant Staphylococcus aureus (S aureus, MRSA) continue to pose therapeutic challenges. Most MRSA strains remain susceptible to older antimicrobial agents such as trimethoprim-sulfamethoxazole (TMP-SMX);1 however, few randomised trials have evaluated its efficacy compared to current standard treatment options (vancomycin, daptomycin, linezolid).2 ,3 A single randomised controlled trial conducted more than two decades ago suggested that TMP-SMX may be a useful alternative to vancomycin for treatment of severe S aureus infections.4 This clinical trial examined whether TMP-SMX is non-inferior compared with vancomycin, for the treatment of …
Competing interests SH has received peer-reviewed research grants funded by Pfizer and B Braun, and is a member of the advisory boards of Destiny Pharma, bioMérieux, Novartis and DaVolterra.
Patient consent Obtained.
Provenance and peer review Commissioned; internally peer reviewed.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.