Context

Despite decreasing incidence in many countries, severe infections caused by methicillin-resistant Staphylococcus aureus (S aureus, MRSA) continue to pose therapeutic challenges. Most MRSA strains remain susceptible to older antimicrobial agents such as trimethoprim-sulfamethoxazole (TMP-SMX);1 however, few randomised trials have evaluated its efficacy compared to current standard treatment options (vancomycin, daptomycin, linezolid).2 ,3 A single randomised controlled trial conducted more than two decades ago suggested that TMP-SMX may be a useful alternative to vancomycin for treatment of severe S aureus infections.4 This clinical trial examined whether TMP-SMX is non-inferior compared with vancomycin, for the treatment of …