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Prediction rule
Anatomic and functional testing for coronary artery disease in symptomatic patients yield similar cardiovascular outcomes
  1. David E Winchester
  1. Department of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
  1. Correspondence to : Dr David E Winchester, Department of Cardiovascular Medicine, University of Florida College of Medicine, 1600 SW Archer Road, P.O. Box 100277, Gainesville, FL 32610-0277, USA; david.winchester{at}

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For patients with symptoms suggestive of cardiac ischaemia and without known coronary artery disease (CAD), a variety of non-invasive testing options are available. Evidence of which option might be superior is lacking. The primary objective of the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial was to compare functional versus anatomic testing in symptomatic patients; investigators hypothesised that visualisation of coronary anatomy would lead to superior cardiovascular outcomes.


This randomised, pragmatic, comparative effectiveness study was sponsored with government funding from the National Heart, Lung and Blood Institute. Symptomatic patients were randomly assigned to the functional …

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  • Competing interests DEW served as a site investigator for the PROMISE trial.

  • Provenance and peer review Commissioned; internally peer reviewed.