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Cohort study
High-sensitivity cardiac troponin T in isolation has limited diagnostic utility in identifying cardiac causes of syncope
  1. Venkatesh Thiruganasambandamoorthy,
  2. Jeffrey J Perry
  1. Department of Emergency Medicine, University of Ottawa, Ottawa, Ontario, Canada
  1. Correspondence to: Dr Venkatesh Thiruganasambandamoorthy, Clinical Epidemiology Unit, F6, 1053 Carling Avenue, Ottawa, Ontario, Canada K1Y 4E9; vthirug{at}

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Commentary to: Christ M, Geier F, Popp S, et al., Diagnostic and prognostic value of high-sensitivity cardiac troponin T in patients with syncope. Am J Med 2015;128:161–170.e1.


During acute syncope management, cardiac causes (acute myocardial infarction (AMI), dysrhythmias or structural heart disease) are a concern and, hence, most patients have cardiac troponin (cTn) tests performed. While it can diagnose AMI, the role of cTn in identification of patients with underlying dysrhythmias or serious structural heart disease is unknown. With new high-sensitivity assays detecting even lower cTn levels, it is unclear if cTn levels can identify or predict non-cardiac serious conditions. This study examines the diagnostic accuracy of high-sensitivity cardiac troponin T (cTnThs) for cardiac syncope and its predictive value for short-term (30 days) …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.