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Randomised controlled trial
α-channel and calcium-channel blockers are ineffective as medical expulsive therapy for ureteral stones regardless of size and location
  1. Andrew Worster
  1. McMaster University, Hamilton, Ontario, Canada
  1. Correspondence to : Dr Andrew Worster, McMaster Clinic, Hamilton General Hospital, Room 248, 237 Barton Street, East Hamilton, ON L8L 2X2, Canada; worster{at}

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Ureteral stones are a common painful condition often requiring medical care, although treatment is usually symptomatic as most stones pass within 6 weeks.1 ,2 Failed expectant management, obstruction and infection are the most common reasons for intervention. Therapies that facilitate stone passage will thereby reduce the symptom duration, need for intervention and probability of complications. Ureteric smooth muscle relaxants have been studied as potential medical expulsive therapies (MET) and the most recent systematic review advocates their use. However, the high risks of selection, allocation and ascertainment bias in the included trials and the inexplicit and subjective primary outcome resulted in high heterogeneity.3 This …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.