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Systematic review with meta analysis
In knee osteoarthritis, pharmacological interventions, with the exception of acetaminophen, significantly improve pain; with intra-articular administration being more effective
  1. Bryan M Saltzman,
  2. Kirk A Campbell
  1. Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, USA
  1. Correspondence to : Dr Kirk A Campbell, Department of Orthopaedic Surgery, Rush University Medical Center, W Harrison St Suite 300, Chicago, IL 60612, USA; Kirk.anthony{at}

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Commentary on: OpenUrlCrossRefPubMed


Knee osteoarthritis (OA) is a progressive degenerative disease affecting many individuals worldwide. Owing to high disease burden and increasing healthcare costs, the relative efficacy of different treatment options have been extensively studied.1 ,2 There have been numerous studies comparing effectiveness of various medications including acetaminophen, anti-inflammatories, intra-articular (IA) corticosteroids, IA-hyaluronic acid (HA), and oral and IA-placebo. This systematic review and network meta-analysis examined randomised controlled trials (RCTs) comparing different treatments for knee OA in order to determine the best treatment option.


A systematic review of RCTs of patients with symptomatic primary knee OA that compared at least two interventions and reported data for …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.