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  • A supplementation of DHA and AA to human milk-fed VLBW infants has no significant cognitive improvement or measurable neuroanatomical effects when evaluated at 8 years of age

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Therapeutics/Prevention
Randomised controlled trial
A supplementation of DHA and AA to human milk-fed VLBW infants has no significant cognitive improvement or measurable neuroanatomical effects when evaluated at 8 years of age
  1. Ryszard Lauterbach
  1. Department of Neonatology, Jagiellonian University Cracow, Cracow, Poland
  1. Correspondence to : Dr Ryszard Lauterbach, Department of Neonatology, Jagiellonian University Cracow, 23 Kopernika str, Cracow 31-501, Poland; ryszard{at}lauterbach.pl

https://doi.org/10.1136/ebmed-2015-110242

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    Commentary on: Almaas AN, Tamnes CK, Nakstad B, et al. Long-chain polyunsaturated fatty acids and cognition in VLBW infants at 8 years: an RCT. Pediatrics 2015;135:972–80.OpenUrlAbstract/FREE Full Text

    Context

    There have been several lines of evidence suggesting that long-chain polyunsaturated fatty acids (LC-PUFAs) are important for the function of the brain at the cellular and neurobiological level. In particular, the concentration of docosahexaenoic acid (DHA) can influence the neuronal membrane fluidity and structure of neurons.1 The last trimester of gestation and the first 1.5 years of life are known in human development as the brain growth spurt stage, and characterised by rapid rate deposition of DHA and arachidonic acid (AA) within the cerebral cortex. Prematurely delivered very low birthweight (VLBW) infants miss intrauterine nutrient accretion and have limited LC-PUFAs stores. Human milk is an important source of DHA and AA. However, it is …

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    Footnotes

    • Competing interests None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.