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Systematic review with meta analysis
Directly observed treatment is not the only solution for poor adherence and low cure of tuberculosis
  1. Surendra K Sharma,
  2. Saket Jha
  1. Department of Internal Medicine, AIIMS, New Delhi, India
  1. Correspondence to : Dr SK Sharma, WHO Collaborating Centre for Research and Training in Tuberculosis; Centre of Excellence in Extrapulmonary TB; Ministry of Health and Family Welfare, Government of India, Department of Internal Medicine, AIIMS, Room No 3097, 3rd Floor, Teaching Block, AIIMS, New Delhi 110029, India; sksharma.aiims{at}

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Commentary on: OpenUrlPubMed


Directly observed therapy (DOT), a component of DOTS (directly observed therapy short course), is arguably one of the most successful public health programmes bringing a paradigm shift in curbing the deadly menace of tuberculosis (TB). Evidence shows that DOT improved adherence and cure rate during the late 1990s.1 Despite the availability of effective treatment, TB continues to be a global leader of morbidity, mortality and economic burden.2 Recently, questions have been raised on the efficacy of all forms of DOT, be it observed by health professionals, community health workers or family members. This systematic review examines the effectiveness of DOT with self-administered treatment (SAT) and various other forms of DOT, including home versus health facility and …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.