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For many years, it has been well documented that combined oral contraceptives (COCs) increase the risk of venous thromboembolism events (VTEs). The VTE risk may vary according to different characteristics of COCs, such as oestrogen dose and type of progestins. COCs are some of the most commonly proposed birth control methods, used by several million women worldwide. Formulations of COCs have dramatically changed over the past 50 years. The new combinations containing cyproterone, drospirenone or norgestimate, associated with low doses of ethinyl-oestradiol, have been recently investigated, but some studies have insufficient power to estimate the risks for these recent …
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.