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Therapeutics/Prevention
Randomised controlled trial
Low-molecular-weight heparin offers no benefit to patients with unexplained recurrent miscarriage in future pregnancy
  1. Katie Field
  1. Department of Obstetrics and Gynaecology, Trintiy College Dublin, St James Hospital, Dublin, Ireland
  1. Correspondence to : Dr Katie Field, Department of Obstetrics and Gynaecology, Trintiy College Dublin, St James Hospital, Dublin 8, Ireland; fieldk{at}tcd.ie

https://doi.org/10.1136/ebmed-2015-110232

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    Commentary on: Schleussner E, Kamin G, Seliger G, et al., ETHIG II group. Low-molecular-weight heparin for women with unexplained recurrent pregnancy loss: a multicenter trial with a minimislation randomisation scheme. Ann Intern Med 2015;162:601–9OpenUrlCrossRefPubMed.

    Context

    Recurrent miscarriage (RM) has been shown to affect between 1% and–3% of couples trying to conceive and up to 5% of those with two consecutive miscarriages are included. While there are many known risk factors for RM no underlying cause is found in nearly 50% of couples.1 The treatment of RM is usually aimed at the cause, which leaves us with very little to offer those with RM of unknown aetiology, and to date most of the treatment offered is …

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    Footnotes

    • Competing interests None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.