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Therapeutics/Prevention
Randomised controlled trial
Mediterranean diet may reduce Alzheimer's risk
  1. Theodora Psaltopoulou,
  2. Theodoros N Sergentanis
  1. Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece
  1. Correspondence to : Dr Theodora Psaltopoulou, Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 75, M Asias Str, Athens 115 27, Greece; tpsaltop{at}med.uoa.gr

https://doi.org/10.1136/ebmed-2015-110237

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    Commentary on: Valls-Pedret C, Sala-Vila A, Serra-Mir M, et al. Mediterranean diet and age-related cognitive decline: a randomized clinical trial. JAMA Intern Med 2015;175:1094–103OpenUrlCrossRefPubMed.

    Context

    Adherence to a Mediterranean diet has been associated with decreased risk of cognitive impairment.1 According to a recent meta-analysis, high adherence to a Mediterranean diet correlated with 40% decreased risk for this condition.2 The protective effect of a Mediterranean diet appears to span the spectrum of cognitive impairment from mild to advanced, including Alzheimer's disease.2 Nevertheless, current evidence stems from observational studies,1 ,2 which may have biases not present in randomised trials. This randomised clinical trial examines the effect of a Mediterranean diet on age-related cognitive decline.

    Methods

    This was a parallel-group randomised clinical trial (subcohort of the …

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    Footnotes

    • Competing interests None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.