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Randomised controlled trial
Synbiotic yogurt consumption leads to statistical improvements in child health that may not be clinically relevant
  1. Yvan Vandenplas
  1. Department of Pediatrics, Universitair Ziekenhuis Brussel, Brussels, Belgium
  1. Correspondence to : Dr Yvan Vandenplas, Department of Pediatrics, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, Brussels 1090, Belgium; yvan.vandenplas{at}

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Probiotics, prebiotics and the mixture of both (synbiotics) have potential health benefits because of their immunological effects. Before companies can describe the indications, benefit has to be shown through clinical trials. A clinical trial conducted to evaluate the health benefits of daily consumption of synbiotic yoghurt in children is described.


This was a placebo-controlled, randomised and double-blind trial lasting 16 weeks. Daily supplementation of children attending day care centres, with a yogurt containing Streptococcus thermophilus, Lactobacillus bulgaricus and Bifidobacterium animalis subspecies lactis (BB-12) (5×109 cfu/100 mL serving) and 1 g of inulin, was …

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  • Competing interests None declared.