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Ischaemic stroke is a common cause of death and disability worldwide. Intravenous tissue plasminogen activator (tPA) reduces disability when administered up to 4.5 h after symptom onset. In severe strokes, when a proximal large vessel occlusion is present, recanalisation rates with tPA are low. Intra-arterial (IA) thrombectomy techniques, particularly stent-retriever devices, have much higher recanalisation rates. IA therapy may be used either as an adjunct to tPA in patients presenting within 4.5 h or as monotherapy in patients with an exclusion criteria to tPA. This trial aimed to determine if IA therapy, administered up to 6 h after symptom onset, improved …
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.