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Randomised controlled trial
Intra-arterial thrombectomy improves functional outcome when administered up to 6 h after stroke
  1. Michael Mullen
  1. University of Pennsylvania, Philadelphia, Pennsylvania, USA
  1. Correspondence to : Dr Michael Mullen, University of Pennsylvania, 3400 Spruce St, 3 W Gates Building, Philadelphia, PA 19146, USA; michael.mullen{at}

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Ischaemic stroke is a common cause of death and disability worldwide. Intravenous tissue plasminogen activator (tPA) reduces disability when administered up to 4.5 h after symptom onset. In severe strokes, when a proximal large vessel occlusion is present, recanalisation rates with tPA are low. Intra-arterial (IA) thrombectomy techniques, particularly stent-retriever devices, have much higher recanalisation rates. IA therapy may be used either as an adjunct to tPA in patients presenting within 4.5 h or as monotherapy in patients with an exclusion criteria to tPA. This trial aimed to determine if IA therapy, administered up to 6 h after symptom onset, improved …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.