You are here

Article Text

Article menu
Download PDFPDF
Therapeutics/Prevention
Randomised controlled trial
Intra-arterial thrombectomy improves functional outcome when administered up to 6 h after stroke
  1. Michael Mullen
  1. University of Pennsylvania, Philadelphia, Pennsylvania, USA
  1. Correspondence to : Dr Michael Mullen, University of Pennsylvania, 3400 Spruce St, 3 W Gates Building, Philadelphia, PA 19146, USA; michael.mullen{at}uphs.upenn.edu

https://doi.org/10.1136/ebmed-2015-110187

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Commentary on: Berkhemer OA, Fransen PS, Beumer D, et al., MR CLEAN Investigators. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med 2015;372:11–20OpenUrlCrossRefPubMedWeb of Science.

    Context

    Ischaemic stroke is a common cause of death and disability worldwide. Intravenous tissue plasminogen activator (tPA) reduces disability when administered up to 4.5 h after symptom onset. In severe strokes, when a proximal large vessel occlusion is present, recanalisation rates with tPA are low. Intra-arterial (IA) thrombectomy techniques, particularly stent-retriever devices, have much higher recanalisation rates. IA therapy may be used either as an adjunct to tPA in patients presenting within 4.5 h or as monotherapy in patients with an exclusion criteria to tPA. This trial aimed to determine if IA therapy, administered up to 6 h after symptom onset, improved …

    View Full Text

    Footnotes

    • Competing interests None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.