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Systematic review with meta analysis
Postnatal environmental tobacco smoke exposure is associated with objective markers of atopy in preschool-aged children
  1. Jonathan M. Gaffin
  1. Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
  1. Correspondence to : Dr Jonathan Gaffin, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA; jonathan.gaffin{at}

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Up to two in three children have evidence of exposure to environmental tobacco smoke (ETS) in the developed world,1 mostly from parental smoking. ETS has been highly associated with asthma and allergic rhinitis. The mechanism by which ETS influences allergic conditions is unclear. Limitations have included difficulties parsing prenatal versus postnatal exposure, accurate measures of exposure and unbiased measures of health outcomes. This systematic review and meta-analysis examines the relationship of postnatal exposure to ETS with objective markers of atopy.


Observational studies of children aged 0–18 years old for the …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.