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Systematic review with meta-analysis
Longer dual antiplatelet therapy (DAPT) after percutaneous coronary intervention has higher anti-ischaemic efficacy than shorter DAPT but is associated with more frequent bleeding
  1. Eliano P Navarese
  1. SIRIO 2 Systematic Investigation and Research on Interventions and Outcomes (SIRIO) MEDICINE Research Network and Heinrich-Heine-University, Düsseldorf, Germany
  1. Correspondence to : Dr Eliano P Navarese, Division of Cardiology, Pulmonology and Vascular Medicine, Department of Internal Medicine, Heinrich-Heine-University, Moorenstr. 48, Düsseldorf 40225, Germany; elianonavarese{at}

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Dual antiplatelet therapy (DAPT) with aspirin plus a P2Y12 receptor antagonist is recommended after drug eluting stent implantation (DES) for at least 12 months by the American College of Cardiology/American Heart Association1 and for 6–12 months by European guidelines. Recent randomised controlled trials (RCT) suggested comparable efficacy of short-term DAPT versus therapy of at least 12 months, raising the question of whether prolonged DAPT offers clinical benefit. However, concerns about DES have arisen regarding the propensity …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.