Article Text

Download PDFPDF
Randomised controlled trial
Supplemental oxygen in patients without hypoxia in ST segment elevation myocardial infarction increases myocardial injury and infarct size
  1. Gabriele Crimi
  1. SC Cardiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  1. Correspondence to : Dr Gabriele Crimi, SC Cardiologia, Fondazione IRCCS Policlinico San Matteo, Piazzale Golgi 1, Pavia 27100, Italy; gabrielecrimi{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Commentary on: OpenUrlAbstract/FREE Full Text


In patients with ST segment elevation myocardial infarction (STEMI), timely reperfusion, best obtained with primary percutaneous coronary intervention (pPCI), is a mainstay to reduce infarct size (IS) and improve clinical outcome. Routine oxygen administration in normoxic patients with STEMI before pPCI, while mentioned by international guidelines,1 is not supported by randomised evidence. Stub and colleagues performed the AVOID study to compare oxygen supplementation (8 L/min) versus no supplementation in patients with STEMI undergoing primary PCI.


The authors conducted a multicentre prospective randomised controlled trial in Melbourne, Australia. Patients were screened and randomised by paramedics: any patient with chest pain <12 h and ECG evidence of STEMI was eligible. Patients with …

View Full Text


  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.