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A number of studies have been performed regarding non-steroidal anti-inflammatory drugs (NSAIDs) and the combination with caffeine for the control of postoperative pain; most of them involving molar surgeries and tension headaches; none of them have been developed in the past 10 years. This study presented by Derry and colleagues assessed the analgesic efficacy of a single dose of ibuprofen plus caffeine when compared to placebo for moderate to severe postoperative pain.
Up to February 2015, the authors searched the Cochrane Central Register of Control Trials, MEDLINE, EMBASE and the Oxford Pain Relief Database. Two independent authors assessed the search results and agreed which …
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