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Systematic review with meta analysis
The effectiveness of a single dose of oral ibuprofen plus caffeine in acute postoperative pain in adults
  1. Sergio Bergese,
  2. Karina Castellon-Larios
  1. Department of Anesthesiology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA
  1. Correspondence to : Dr Sergio Bergese, Department of Anesthesiology, The Ohio State University Wexner Medical Center, 410 West 10th Ave, Columbus, OH 43210, USA; sergio.bergese{at}

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A number of studies have been performed regarding non-steroidal anti-inflammatory drugs (NSAIDs) and the combination with caffeine for the control of postoperative pain; most of them involving molar surgeries and tension headaches; none of them have been developed in the past 10 years. This study presented by Derry and colleagues assessed the analgesic efficacy of a single dose of ibuprofen plus caffeine when compared to placebo for moderate to severe postoperative pain.


Up to February 2015, the authors searched the Cochrane Central Register of Control Trials, MEDLINE, EMBASE and the Oxford Pain Relief Database. Two independent authors assessed the search results and agreed which …

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  • Contributors SB and KC-L had substantial contributions to the conception and interpretation of the data. KC-L drafted the work and revised critically for important intellectual content. SB approved the final version of the manuscript.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.