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Systematic review with meta analysis
The effectiveness of a single dose of oral ibuprofen plus caffeine in acute postoperative pain in adults
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  • Published on:
    Judging evidence in postoperative analgesia

    Dear Editor,

    First, thank you for highlighting our paper. However, I do want to take issue with this commentary.

    Systematic reviews in postop analgesia have been done now for over 20 years, and there is considerable methodological research to substantiate what is done. The results are robust and trustworthy.

    Single trials, however well done, are not trustworthy because while they may be powered t...

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    Conflict of Interest:
    None declared.