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It is clear that the successful treatment of HIV infection requires that patients be diagnosed, be engaged in regular care and receive and adhere to effective antiretroviral therapy (ART). When to start ART has been less clear. WHO guidelines have evolved over time from reserving therapy for the most immunocompromised in September 2015 treating all patients with HIV infection.1 Two large well-conducted randomised controlled trials (RCTs), the Strategic Timing of Antiretroviral Therapy (START) trial2 and the TEMPRANO ANRS 12136,3 have been particularly important in advancing the evidence base for universal therapy.
START was designed and conducted by the International Network for Strategic Initiatives …
Contributors GWR wrote the manuscript. AA contributed to the analysis, reviewed and approved the manuscript.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.