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As recent systematic reviews have demonstrated, associations documented in observational studies between low vitamin D status and a wide range of disease outcomes have generally not been borne out by randomised control trials conducted thus far1; even for the traditional vitamin D-related outcomes of bone mineralisation and muscle function, such intervention studies have not provided a uniform message.2 Indeed there is continued controversy regarding what constitutes an optimal serum 25-hydroxyvitamin D concentration [(25OH)D].3
Against this backdrop, Hanson et al aimed to …
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.