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Therapeutics/Prevention
Randomised controlled trial
High-dose vitamin D supplementation does not alter bone mass or muscle function over 1 year in postmenopausal women
  1. Nicholas C Harvey1,2,
  2. Cyrus Cooper1,2,3
  1. 1MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK;
  2. 2NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK;
  3. 3NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK
  1. Correspondence to : Professor Cyrus Cooper, MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK; cc{at}mrc.soton.ac.uk
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http://dx.doi.org/10.1136/ebmed-2015-110328

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    Commentary on: Hansen KE, Johnson RE, Chambers KR, et al. Treatment of vitamin D deficiency in postmenopausal women: a randomised clinical trial. JAMA Intern Med 2015;175:1612–21.OpenUrlCrossRefPubMed

    Context

    As recent systematic reviews have demonstrated, associations documented in observational studies between low vitamin D status and a wide range of disease outcomes have generally not been borne out by randomised control trials conducted thus far1; even for the traditional vitamin D-related outcomes of bone mineralisation and muscle function, such intervention studies have not provided a uniform message.2 Indeed there is continued controversy regarding what constitutes an optimal serum 25-hydroxyvitamin D concentration [(25OH)D].3

    Methods

    Against this backdrop, Hanson et al aimed to …

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