Article Text

Download PDFPDF
Systematic review with meta analysis
Observational studies are compatible with an association between saturated and trans fats and cardiovascular disease
  1. Lee Hooper1,
  2. Jim Mann2
  1. 1Norwich Medical School, University of East Anglia, Norwich, UK;
  2. 2Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
  1. Correspondence to : Dr Lee Hooper, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK; l.hooper{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Commentary on:


What is the relationship between saturated or trans fats in our food and cardiovascular risk? To find out we must examine the totality of interventional and observational evidence and all appropriate outcomes. The WHO Nutrition Guidance Advisory Group (WHO NUGAG) recently commissioned systematic reviews of randomised controlled trials (RCTs) which examined effects of modifying saturated or trans fat intakes on mortality or cardiovascular health1 ,2 and controlled trials on lipid outcomes (updates of these published reviews are due to be published),3 ,4 as well as this systematic review of observational data (reported by de Souza and colleagues).


This systematic review included observational …

View Full Text


  • Contributors LH wrote the first draft of this article, JM commented and discussed, then both authors agreed the final version.

  • Competing interests LH, JM and Russel de Souza have worked with WHO NUGAG in developing the evidence to underpin dietary guidance.

  • Provenance and peer review Commissioned; internally peer reviewed.