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Randomised controlled trial
Aerobic exercise training reduces bronchial hyper-responsiveness and serum pro-inflammatory cytokines in patients with asthma
  1. Stefano R del Giacco1,
  2. Vanessa Garcia-Larsen2
  1. 1Department of Medical Sciences “M Aresu”, University of Cagliari, Cagliari, Italy;
  2. 2Department of Respiratory Epidemiology, Occupational Medicine and Public Health Group, Imperial College London, London, UK
  1. Correspondence to : Dr Stefano R del Giacco, Department of Medical Sciences “M Aresu”, University of Cagliari, Cittadella Universitaria, Asse Didattico “E1” Medicina, 09042, Monserrato, Cagliari, Italy; stedg{at}

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Exercise is a well-known trigger for asthma symptoms. In patients with asthma, strenuous physical activity increases the risk of an asthma attack, with a ‘U’-shaped curve showing that moderate exercise training carries a lower risk of asthma compared to high-intensity exercise training. Lack of physical activity appears to be independently associated with increased bronchial hyper-responsiveness (BHR).1 These observations are confirmed by a growing number of murine studies, but reviews examining the epidemiological evidence for such associations in humans show that the overall evidence on exercise and asthma is, at best, very …

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  • Competing interests None declared.

  • Ethics approval Ethics Review Board of the Clinical Hospital (protocol 0121/10).

  • Provenance and peer review Commissioned; internally peer reviewed.