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Randomised controlled trial
Mediterranean diet supplemented with extra virgin olive oil reduces the incidence of invasive breast cancer in a randomised controlled trial
  1. Georg Hoffmann,
  2. Lukas Schwingshackl
  1. University of Vienna, Vienna, Austria
  2. German Institute of Human Nutrition, Nuthetal, Germany
  1. Correspondence to : Professor Georg Hoffmann, University of Vienna, Althanstraße 14, A-1090 Vienna, Austria; georg.hoffmann{at}

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Commentary on: OpenUrlCrossRefPubMed


A Mediterranean dietary (MedD) pattern has been associated with a number of beneficial effects. Thus, recent meta-analyses could show an inverse association between high adherence to a MedD pattern and overall cancer mortality, as well as incidence of various types of cancer.1–3 However, these associations have been exclusively based on the synthesis of results derived from observational studies.


The PREDIMED study was a Spanish multicentre randomised single blind controlled trial including 7447 participants at high risk of, but without manifested cardiovascular diseases. The subanalysis presented by Toledo and co-workers included 4282 postmenopausal women (4152 without previous history of breast cancer) who had been allocated into two dietary …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.