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Randomized controlled trial
Maternal postpartum high-dose vitamin D3 supplementation (6400 IU/day) or conventional infant vitamin D3 supplementation (400 IU/day) lead to similar vitamin D status of healthy exclusively/fully breastfeeding infants by 7 months of age
  1. Daniel E Roth
  1. Department of Paediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
  1. Correspondence to : Dr Daniel E Roth Department of Paediatrics, The Hospital for Sick Children and University of Toronto 686 Bay Street, Toronto, ON, Canada M5G 0A4; daniel.roth{at}

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Routine vitamin D supplementation (400 IU/day) of breastfed infants has been recommended in North America for >50 years.1 Historically, the practice was advocated to prevent rickets; recently, there has been greater emphasis on its role in maintaining serum 25-hydroxyvitamin D concentrations (25(OH)D) above conventional thresholds of sufficiency (eg, 50 nmol/L).2 Yet, some breastfeeding advocates have argued that this policy conflicts with the message that mother's milk is a complete source of nutrient requirements in the first 6 months of life. The recognition that breast milk vitamin D inadequacy reflects maternal vitamin D insufficiency has prompted efforts to define maternal postpartum vitamin …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.