Table of contents

Therapeutics/Prevention

• Randomised controlled trial: Filtered sunlight reduces serum bilirubin levels as effectively as conventional phototherapy in late preterm and term neonates with mild jaundice (2 February, 2016)

  Praveen Kumar
• Cost effectiveness study: Cardiac resynchronisation therapy with an implantable cardioverter defibrillator appears to be cost-effective in patients with mild heart failure (17 February, 2016)

  Keith Cooper
• Systematic review with meta analysis: Appropriate design, methodological quality assessment, and clinically relevant outcomes are essential to determine the therapeutic role of epidural injections for low back pain and radiculopathy (17 February, 2016)

  Mark V Boswell, Laxmaiah Manchikanti
• Systematic review with meta analysis: Drug-eluting stents and drug-eluting balloons are the best strategies to treat coronary in-stent restenosis (10 February, 2016)

  Gennaro Giustino, Roxana Mehran
• Randomised controlled trial: Revascularisation plus supervised exercise is superior to supervised exercise alone for the treatment of intermittent claudication (10 February, 2016)

  Sreekanth Vemulapalli
• Randomised controlled trial: Both paroxetine and imipramine appear to be ineffective in adolescents with major depression, furthermore doubts have risen about their safety (17 February, 2016)

  T K Birkenhager
• Systematic review with meta analysis: In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery (24 February, 2016)

  Christoph Bührer
• Systematic review with meta analysis: Antenatal dietary education and/or balanced nutritional supplementation benefits at-risk women and infants (3 March, 2016)

  Zulfiqar A Bhutta
• Systematic review: Limited data suggest that otherwise healthy school-aged children with obstructive sleep disordered breathing have some benefit from adenotonsillectomy compared with non-surgical treatment (8 March, 2016)

  Susan L Garetz
• Randomised controlled trial: New reversal agent for factor Xa inhibitors shows promise (7 March, 2016)

  Kamrouz Ghadimi, Ian J Welsby
• Systematic review with meta analysis: Prophylactic tranexamic acid in addition to uterotonics may prevent blood loss for vaginal and caesarean deliveries (7 April, 2016)

  Loïc Sentilhes, Catherine Deneux-Tharaux
• Observational study:

  Many US adults with controlled type 2 diabetes receive frequent HbA_1c testing and possible overtreatment

  (25 March, 2016)

  Neda Laiteerapong
• Randomised controlled trial: Antiretroviral pre-exposure prophylaxis for HIV prevention is highly effective in community settings (30 March, 2016)

  Angela Robertson Bazzi
• Randomised controlled trial: High-sensitivity troponin predicts coronary disease outcomes in type 2 diabetes but yields no benefit in selecting patients for revascularisation (13 April, 2016)

  Juhani Junttila
• Randomised controlled trial: In hypertensive patients with elevated risk of cardiovascular disease, targeting systolic blood pressure to less than 120 mm Hg significantly reduces the rate of fatal and non-fatal cardiovascular events as well as death from any cause (23 March, 2016)

  Mina Owlia, Sripal Bangalore
• Systematic review with meta analysis:

  Treatment for chronic Strongyloides stercoralis infection: moderate-to-low evidence shows that ivermectin is more effective and tolerable than albendazole and thiabendazole, respectively

  (25 April, 2016)

  Dora Buonfrate, Federico Gobbi
• Systematic review with meta analysis: No new evidence to support the routine use of steroids in the treatment of infectious mononucleosis (20 April, 2016)

  Paul Lennon
• Randomized clinical trial: Detemir is non-inferior to NPH insulin in women with pregestational type 2 diabetes and gestational diabetes mellitus (3 February, 2016)

  Priyathama Vellanki, Guillermo Umpierrez
• Randomised controlled trial: Adjunctive use of intrapartum foetal ST-segment analysis (STAN) confers no benefit over conventional foetal heart rate monitoring (16 March, 2016)

  Alexandros Lazaridis, Christoph C Lees