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Hypertension is among the most significant modifiable risk factor for cardiovascular disease, yet there is considerable debate on the optimal blood pressure (BP) goal. Observational studies1 and the ACCORD trial2 suggest a target organ heterogeneity in that with lower systolic BP goals (<120 mm Hg) the risk of cerebrovascular events are reduced, but not coronary events. As such, systolic BP goals of <130, <140 or <150 mm Hg, have been proposed in the last decade by hypertension guideline societies.3 ,4
SPRINT was a randomised, controlled, open-label trial of targeted BP treatment to the standard BP goal (<140 mm Hg) compared …
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.