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Infectious mononucleosis (IM) is a non-genetic syndrome, with the classic triad of fever, pharyngitis and cervical lymphadenopathy, and lymphocytosis. Over 90% of cases are caused by the Epstein-Barr virus, a subclinical infection in childhood, to which 95% of the population have seroconverted by adolescence.1 Infection after this time will result in IM, a more severe illness than bacterial tonsillitis.2 Attempts are ongoing to expand the treatment armamentarium.3 Some reports supported the use of corticosteroids, but others showed these effects to be short lived. A Cochrane review, in 2006, concluded that there was insufficient evidence and the trials were too few, heterogeneous and of poor quality to recommend steroid …
Collaborators Michael Crotty and John E Fenton.
Contributors PL was invited to comment on the systematic review and meta analyses by Rezk et al as per the journal guidelines. MC and JEF, co-authors of PL on a review written about infectious mononucleosis, edited the manuscript prior to submission.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.