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Chest pain is the second most common reason patients visit emergency departments (EDs), and substantial healthcare resources are expended in its evaluation and management.1 Accurately identifying patients with acute coronary syndrome (ACS) is an ongoing diagnostic challenge, and much past and ongoing research is being conducted in this area. Several contemporary risk scores have been developed to predict ACS risk in ED patients with undifferentiated chest pain, and the field is rapidly evolving as new cardiac biomarkers are developed to address the diagnostic challenge. It is in this context—identifying patients at risk for ACS in a cohort of ED patients with non-traumatic chest pain—that …