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  • Revascularisation plus supervised exercise is superior to supervised exercise alone for the treatment of intermittent claudication

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Therapeutics/Prevention
Randomised controlled trial
Revascularisation plus supervised exercise is superior to supervised exercise alone for the treatment of intermittent claudication
  1. Sreekanth Vemulapalli
  1. Division of Cardiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
  1. Correspondence to : Dr Sreekanth Vemulapalli, Division of Cardiology, Duke Clinical Research Institute, Duke University Medical Center, P.O. Box 3126, Durham, NC 27710, USA; sreekanth.vemulapalli{at}duke.edu

https://doi.org/10.1136/ebmed-2015-110360

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    Commentary on: Fakhry F, Spronk S, van der Laan L, et al. Endovascular revascularization and supervised exercise for peripheral artery disease and intermittent claudication: a randomized clinical trial. JAMA 2015;314:1936–44.OpenUrlCrossRefPubMed

    Context

    Intermittent claudication (IC) is the most frequent symptomatic manifestation of peripheral artery disease and is estimated to affect 20–40 million people worldwide.1 Previous underpowered comparative effectiveness studies of treatment modalities arrived at mixed conclusions about the combined effect of supervised exercise and revascularisation.2 ,3

    Methods

    This study was a multicentre (10 sites), parallel-design randomised controlled trial of supervised exercise plus endovascular revascularisation versus supervised exercise alone for IC.4 Patients with IC and one or more stenotic lesions at the aortoiliac and/or femoropopliteal level amenable to endovascular therapy were eligible. Supervised …

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    Footnotes

    • Competing interests None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.